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Posts Tagged ‘outbreak’

The Stuxnet outbreak: A worm in the centrifuge

An unusually sophisticated cyber-weapon is mysterious but important

IT SOUNDS like the plot of an airport thriller or a James Bond film. A crack team of experts, assembled by a shadowy government agency, develops a cyber-weapon designed to shut down a rogue country’s nuclear programme. The software uses previously unknown tricks to worm its way into industrial control systems undetected, searching for a particular configuration that matches its target—at which point it wreaks havoc by reprogramming the system, closing valves and shutting down pipelines.

This is not fiction, but fact. A new software “worm” called Stuxnet (its name is derived from keywords buried in the code) seems to have been developed to attack a specific nuclear facility in Iran. Its sophistication suggests that it is the work of a well-financed team working for a government, rather than a group of rogue hackers trying to steal secrets or cause trouble. America and Israel are the obvious suspects. But Stuxnet’s origins and effects are unknown. …

Disaster-hit Philippines seeks help on outbreak: WHO

The Philippines is seeking international help to fight a deadly outbreak of an infectious disease following two devastating tropical storms, the World Health Organisation said Thursday. Filipino health authorities said leptospirosis, a bacterial infection, has infected 1,963 people and

WW2 outbreak marked in Belgrade

Wreaths have been laid at the Yugoslav-Polish League memorial in Belgrade to mark the 70th anniversary of the outbreak of World War 2. Wreaths were laid by Labor State Secretary Zoran Martinović, Belgrade Mayor Dragan Đilas amd Polish Charge d’Affaires Pawel Czerwinski.

Influenza vaccination: How to stop an outbreak

A mathematical model suggests a new way to allocate vaccines

THE existing formula is simple. When vaccinating against influenza, inoculate those most susceptible to the disease’s wrath. Such vulnerable types include the elderly (who are the most likely to die if infected) and infants (whose immune systems are not fully developed). This seems a reasonable policy, and it is the one that has long been promulgated by America’s Centres for Disease Control (CDC). Only recently has it been extended to include children up to the age of 18, on the basis that they are more likely than other people to catch flu in the first place, through enforced socialising at school—even though they are at little risk of dying from it.

According to Jan Medlock of Clemson University in South Carolina, and Alison Galvani of Yale, however, vaccinating those most at risk of bad effects is not the right way to deal with the disease. In a report published this week in Science, they argue that even with the extension of vaccination to school-age children, the existing policy of protecting the individual is still playing down the real public-health value of vaccines—namely that they create a so-called herd immunity which helps to break the disease’s chain of transmission. …

Scientists decoding genomic sequences of swine flu virus from Argentina

In a new study, researchers are decoding the complete genomic sequences of Swine flu pandemic (H1N1) 2009 virus from patients with severe respiratory disease in Argentina.
For the study, the researchers will be comparing sequences of viruses associated with the current outbreak in Argentina with those found in other locations.
The researchers are aiming to determine whether [...]

Scottish swine flu ‘may have peaked’

Expected decline in cases could be followed by similar tailing off in England within weeks
• Datablog: full list of swine flu cases

The current swine flu outbreak may now have peaked in Scotland, experts believe, suggesting that the surge in cases in England will subside within weeks.

One of the UK’s leading bacteriologists, Professor Hugh Pennington, said this morning that Scotland was “possibly through the worst of this phase of the virus”.

Despite a steep increase in cases in England, it is expected the latest Scottish estimated figures will show a decline when they are released later today after cases in the worst hotspots – Glasgow and Paisley – began to tail off earlier this month.

As a result, Scottish health ministers are not following moves in England to set up a national flu pandemic helpline because existing NHS services are able to cope with the current rate of cases.

The H1N1 virus caught hold in Scotland more quickly, after the first cases in the UK emerged in the small town of Polmont near Falkirk in April, and the first death of a swine flu patient outside the Americas.

To the surprise of experts, the virus was confined largely to three clusters – in southern Glasgow, Paisley and Dunoon, which erupted in May and June. The outbreak in Dunoon subsided quickly. Reported flu cases in the greater Glasgow area – which saw the first swine flu deaths in the UK – have also declined.

Last week, the Scottish health secretary, Nicola Sturgeon, said the overall rate of people reporting flu-like symptoms was not significantly higher than normal for this time of year. She said there were “encouraging signs” that cases were declining in the Glasgow area.

Prof Pennington, speaking on BBC Radio Scotland this morning, also cautioned against the rush to set up mass vaccinations of the population before the vaccine had been fully tested – a move being considered by ministers.

He said proposals to bypass normal testing procedures were laid out in the flu pandemic plan, but this virus was not proving as fatal or virulent as predicted in the plans. Pennington suggested it may be wiser to wait until the vaccine had been fully tested and if necessary altered before rushing it out.

The Guardian revealed today that Scotland’s flu pandemic plans – drafted last year before the swine flu outbreak – had predicted that the next major outbreak could kill between 5,100 and 63,570 people in Scotland alone, in a matter of weeks.

But the highest mortality rate was based on the virus infecting 50% of the population and killing 2.5% of those infected. The mass vaccination plans are based partly on this official modelling. However, the H1N1 virus is far less virulent, although officials do fear the mortality rate could increase this winter, and get close to the 5,100 figure.

Pennington said: “Once the initial tests have been done I think there is a possibility – laid out in the pandemic plan – that we could use emergency procedures just to rush it through before all the test results have been analysed and completed.

“I’d be concerned about that because the pandemic plan was looking really at a virus that was much higher mortality than the one we’re seeing now, the one we’re seeing now is basically no different in that respect from seasonal flu.”

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McDonald’s Sued After Hepatitis Outbreak

CHICAGO (AP) — An attorney who specializes in food safety filed a lawsuit Tuesday against McDonald’s following a hepatitis A outbreak in northwestern Illinois.

The lawsuit was filed in Rock Island County Circuit Court on behalf of Cody Patte…

World swine flu death toll tops 700

Pregnant women may be advised to stay home if outbreak worsens in autumn, chief medical officer says

More than 700 people have died from the swine flu virus worldwide since H1N1 emerged in April, the World Health Organisation (WHO) said.

Twenty-nine of those deaths have been in the UK but the WHO is no longer giving country-by-country breakdowns.

The global death toll is about 300 up on the 429 reported two weeks ago but since then countries have been told there is no longer any need to report infections.

The figure compares with 262 confirmed deaths from bird flu in 15 countries since 2003.

The WHO report of deaths came as Britain’s chief medical officer, Sir Liam Donaldson, said pregnant women, cancer patients on chemotherapy and others with weakened immune systems may be advised to stay away from crowds for “a few weeks” when the swine flu pandemic reaches its height, probably this autumn.

Mothers-to-be are at present not being recommended to cut back on normal activities such as going to work, using public transport or attending events and family gatherings, but that could change if swine flu reached a level of, for example, one in three of the population.

But Donaldson also said some pregnant women may wish to exercise their choice now “on a highly precautionary basis, to avoid large, densely populated gatherings where they have little control over personal contact”.

Donaldson has been attempting to clarify official advice since confusion emerged at the weekend over exactly what it meant.

Guidance was posted on the Department of Health website yesterday and this morning the chief medical officer returned to the subject on GMTV.

“We are not advising pregnant women to cut down on their normal daily activity – some might choose to be very precautionary and not want to go into crowded places, but that is not the advice,” he said.

“But we will look at it again when it comes to the autumn when we get possibly big numbers of cases.

“If we got, for example, one in three of the population affected by flu, which is one of the estimates, at that point I may advise pregnant women and people for example on cancer treatment who have weakened immune systems to avoid crowded places for a period of a few weeks when it is at its peak.”

His remarks came as ministers were urged to rethink their policy of keeping schools open through the pandemic after research showed that a shutdown would curb the spread of infection and limit the number of deaths.

Two infectious disease experts said school closures should be considered to reduce the number of cases and buy time until a vaccine is available.

Schools across Britain have broken up for summer holidays and experts hope this will help to slow the spread of the virus. But there are fears that when classes resume in the autumn the number of cases will increase rapidly.

School closures would cause serious difficulties for working parents, lead to a 1% loss in GDP through absenteeism and see as many as 30% of NHS staff taking time off just when they are needed to treat patients.

In a study published in the Lancet Infectious Diseases, government adviser Prof Neil Ferguson and Dr Simon Cauchemez, both of the department of infectious disease epidemiology, Imperial College London, said “prolonged” closures could reduce the scale of the outbreak by 13-17% and at the pandemic’s peak the shutting of schools could bring down the number of cases by 38-45%.

“It is therefore hoped that closure of schools during the pandemic might break the chains of transmission, with the following potential benefits: reducing the total number of cases; slowing the epidemic to give more time for vaccine production; and reducing the incidence of cases at the peak of the epidemic, limiting both the stress on healthcare systems and peak absenteeism in the general population, and thus increasing community-wide resilience,” the researchers said.

Such a move would also raise the question of what should be done with millions of schoolchildren during a prolonged shutdown, they added. The authors said that governments in Europe and America might have to take such a step after they studied the impact of school closures during flu epidemics in other countries stretching back to 1918.

They say that study of the 1918 flu outbreak in America and Australia indicates that shutting schools, in tandem with closing churches and improved hygiene, could have reduced the death toll by between 10% and 30%, and as much as 50% in some cities at the height of the outbreak.

About 100 schools closed after the start of the outbreak in May but soon reopened when official advice changed because swine flu was becoming so prevalent.

Donaldson responded coolly to the idea during his GMTV appearance. “I think it would take a lot for us to move in that direction. It would be extremely disruptive to society. When would you open them again, given that flu might be around for several months?

“If we look at what we did in the west Midlands for example, where we did very aggressively initially close schools and treat people with Tamiflu who didn’t have symptoms but were contacts of cases, eventually it broke out of the box and spread more widely.”

He added: “I think we will obviously keep all of these things under review as we do with any scientific advice, but at the moment I think it is unlikely.”

The WHO said “it is really up to individual countries to consider what mitigation measures suit them in regard to the situation in individual countries”.

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Global swine flu deaths top 700

Mexico City commuters on the metro

H1N1 swine flu has killed more than 700 people around the world since the outbreak began four months ago, says the World Health Organization (WHO).

This represents a jump of at least two-thirds from the last official death toll figure of 429, published by the WHO on July 6.

Margaret Chan, WHO director-general, has warned that swine flu will become the biggest flu pandemic ever seen.

However, most cases continue to produce only mild symptoms.

SWINE FLU SYMPTOMS

  • 1. High temperature, tiredness and lowered immunity
  • 2. Headache, runny nose and sneezing
  • 3. Sore throat
  • 4. Shortness of breath
  • 5. Loss of appetite, vomiting and diarrhoea
  • 6. Aching muscles, limb and joint pain

Source: NHS

Fergus on Flu

The overwhelming majority of patients usually recover, even without medical treatment, within a week of falling ill.

The WHO has said the pandemic is developing at such a high speed that it is now pointless to try to document every case.

But officials have stressed that there is an ongoing need for all countries to monitor unusual events, such as clusters of severe or fatal cases, or unusual clinical patterns, closely.

WHO spokeswoman Aphaluck Bhatiasevi said officials were examining various measures countries could take to slow the spread of the disease.

She said school closures could be among the recommendations, but that it was up to each country to consider appropriate steps for their situations.</p


This article is from the BBC News website. © British Broadcasting Corporation, The BBC is not responsible for the content of external internet sites.

Swine flu school closures urged

Leading experts say closures may need to be ‘prolonged’ in order to be effective

Closing schools for long periods could reduce the spread of swine flu, ease its burden on hospitals and potentially limit the number of deaths it causes, two leading experts argue today.

The fact that children are more infectious and more vulnerable to the H1N1 virus, resulting in it spreading among them at great speed, means that prolonged closure of schools is necessary, according to Dr Simon Cauchemez and Prof Neil Ferguson of Imperial College London.

The government may need to rethink its existing policy of schools staying open during the pandemic before the UK’s 30,000 primary and secondary schools return from their summer holidays, if swine flu has become more severe by then, warn Cauchemez and Ferguson, who work in Imperial College’s department of infectious disease epidemiology.

The two experts do not specify how long any closure should last but say that it may need to be “prolonged” in order to be effective, and recommend that “it would seem sensible for all countries to at least have plans for reactive closure”.

Around 20 schools in Britain where pupils contracted swine flu were shut in May at the start of the pandemic in an effort to stop it spreading.

But that attempted containment was abandoned when the numbers of people affected rose rapidly. More than 60% of the cases of swine flu so far have been in young people aged 18 or younger, with incidence highest among five- to 15-year-olds.

Writing in the August issue of The Lancet Infectious Diseases, the authors say: “It is … hoped that closure of schools during the pandemic might break the chains of transmission, with the following potential benefits: reducing the total number of cases; slowing the epidemic to give more time for vaccine production; and reducing the incidence of cases at the peak of the epidemic, limiting both the stress on healthcare systems and peak absenteeism in the general population, and thus increasing community cohesion”.

Experience of school closures in other countries during previous flu epidemics in other countries shows that the tactic brings benefits, they say. In Israel in 2000, for example, teachers went on strike during a flu outbreak. When they did fewer people went to see their doctor or hospital emergency department and fewer patients were diagnosed with a respiratory tract infection or viral infections. But when the strike ended and schools opened again, infections resumed rising.

Similarly, a study of school holidays in France between 1984 and 2006 shows that school holidays prevent about one in six cases of flu and suggests that a policy of proactively closing schools as a preventative measure could cut the number of people getting infected by between 13% and 17% and by between 38% and 45% during the peak of the outbreak.

They also say that study of the 1918 flu outbreak in America and Australian cities indicate that shutting schools, in tandem with closing churches and improved hygiene, could have reduce the death toll by between 10% and 30%, and as much as 50% in some cities at the height of the outbreak.

However, the authors also point out that school closures have massive side effects. A 12-week closure would cost between one and six% of GDP, according to UK and American studies. And as many as 30% of the entire NHS workforce may need to be off to look after children. In addition, the question of how children who are off school should mix with each other is “a key uncertainty”.

Headteacher leaders have been calling for teachers to be among the first to be vaccinated along with healthcare workers to prevent the forced widespread closure of schools due to lack of staff.

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6 in 10 Americans believe serious swine flu outbreak likely in fall/winter

Six in ten Americans believe there will be widespread swine flu cases this fall or winter, according to a new survey.
According to the national poll conducted by the Harvard School of Public Health, parents are more likely than people without children to believe this will occur, 65 percent saying it is very or somewhat likely [...]

Guardian Daily: Swine flu fears

Swine flu expert says outbreak surprised scientists; secret CIA anti-terror plan; and Twitter’s Biz Stone, in our daily audio show with Jon Dennis


Health experts ‘surprised’ by UK spread of swine flu

• Scientists were ‘caught napping’ by outbreak, says flu expert
• Under 30s at greatest risk from pandemic

One of the world’s most respected influenza scientists said today that health officials had been surprised by the spread of swine flu.

Dr Alan Hay, director of the London-based World Influenza Centre, said the extensive summer outbreak in Britain had not followed expected patterns and warned the Department of Health needed to be prepared for a more deadly form of the disease.

“We have been a little surprised by the degree of spread of this virus. A few weeks ago we anticipated that this was going to be a short series of outbreaks that would probably peter out before reappearing in the autumn or winter and that has proved not to be the case.”

Hay added:

• Some of the background health concerns noted against flu deaths would not have been fatal, noting an American case where the underlying cause was obesity

• The flu surveillance community had been “caught napping” by the emergence of the swine flu outbreak as most resources were concentrated on guarding against a bird flu pandemic

• He was concerned about the emergence since 2007 of drug-resistant flu, which could impact on the pandemic virus.

Seventeen people in the UK have died after contracting swine flu and 335 people have been treated in hospital after contracting the virus. But tens of thousands are visiting GPs with flu-like symptoms every week, according to the Health Protection Agency. The latest deaths were of a six-year-old girl from north-west London and a GP from Bedfordshire.

Hay, who advises the World Health Organisation on its flu policy, said it had become clear the flu pandemic was predominantly affecting children aged five to 14, with the majority of cases nationally and internationally affecting people under 30. Those born before the 1957 flu pandemic appeared to be particularly resistant to the outbreak, indicating they carried some residual immunity.

Hay said the current outbreak would probably continue for another “week or two” before re-emerging in the autumn and early winter. However, the high level of sufferers now could mean that an autumn outbreak would be less severe.

“We are already experiencing this extensive outbreak of the flu at the present time. The people who are being affected will have reasonable immunity against the virus if it reappears during the winter season, which we anticipate. That will lessen the impact subsequently [on health services],” he said.

“So forecasting what will happen is rather difficult but what the Department of Health has to be prepared for is for there to be significant demand on health services resources.”

Of particular concern was that the virus, which has caused only mild illness in most cases, could become more deadly.

“The concern is that the situation might change, the virus may become more virulent,” Hay said. “The proportion of severe infections might increase. And fatalities might increase. We have been monitoring this quite intensively in the labs all around the world and have been seeing some minor changes in the viruses.”

Hay said there had been a small number of cases of resistance to antiviral drugs but no sustained emergence of resistance.

“We’re not totally sure what to expect. Because on the one hand, prior to a year ago, really the anticipation was for very low levels of drug resistance, and then we had the experience in late 2007 with the emergence of drug resistance of seasonal H1N1. And those emerged to become the predominant seasonal virus that has circulated recently. That was really an unanticipated event. We don’t know what the implications of that are in the emergence of this novel virus. It is a concern.”

Hay concurred that most people who had died from the outbreak had underlying health problems, but said that those may not have been life-threatening.

“Would they have died anyway? I think the answer to that is probably no,” said Hay. “Those who have underlying conditions included one that was identified in the US was obesity. So these people were not going to die of obesity in the next month or two I suspect. Some people may have been in a more critical condition.”

Flu surveillance scientists, who had been concentrating resources on looking for a bird flu pandemic, had been surprised by the swine flu outbreak, he added.

“We were not anticipating a virus of this nature causing a pandemic. All our eyes were focusing on the H5N1 virus that had been circulating in wild and domestic poultry populations.

“We have been observing similar viruses to this pandemic in pigs in the past 10 years in the US. And because it was antigenically related to the viruses already circulating – it was the same H1N1 subtype – it was not perceived as being a major threat. Of course we were caught napping, you might say, but this is what has transpired.

“We don’t really know the way this virus might change as it adapts to the human population and what the consequences of such changes might be.”

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Swine flu tally: 37

37 cases of the H1N1 virus, otherwise known as swine flu, have been registered in Serbia to date. 28 cases arrived in Serbia from a country where the outbreak had already been registered.